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One of the manifestations of different abiotic and biotic stress conditions in plants is the enhanced production of reactive oxygen species (ROS) which can be hazardous to cells

These continuously generated electrophilic hydroperoxy-phospholipids are neutralized by a specific GSH-dependent peroxidase, glutathione peroxidase 4 (GPX4), which prevents them from damaging membranes and driving ferroptotic cell death (7, 8)

Am J Physiol Lung Cell Mol Physiol 291 : L46L57 Hu S, Zhao H, Al-Humadi NH, Yin XJ, Ma JK 2006 Silica-induced apoptosis in alveolar macrophages: evidence of in vivo thiol depletion and the activation of mitochondrial pathway

preclinical, not approved

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